Hi,
I suggest you to delete cookies and temporarily files from your web browser software and turn off the popup blocker. Once you delete cookies and temporarily files, restart your computer and try to save changes on your Microsoft Office Live website by clicking on “Save” tab. I also suggest you to save changes on your website on different computer (which is connected with different ISP) because may be you are facing any issue with your ISP.
Note: Make sure you are not copying and pasting anything from Microsoft Word document to your website.
Note: If issue still persists therefore contact Microsoft Office Live Support Team by following link:
https://support.smallbusiness.officelive.com/default.aspx?scrx=1
Regards,
Ranjeet Mishra